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pentobarbital will minimize the extent or effect of pioglitazone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Insignificant/Importance Mysterious.Contraindicated (1)pentobarbital will lessen the level or influence of cobimetinib by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Steer clear of coadministration